The party's second-in-command has suggested that Andy Burnham could have triumphed in the Gorton and Denton byelection, as she urged her party to make more use of the popular Greater Manchester mayor.
Overcoming a sizable 13,000-vote Labour majority from the last general election, a local Green councillor, a local plumber, was elected as the party's fifth MP on Friday. This occurred in an area that had elected Labour MPs for nearly a century.
The Reform Party's Matt Goodwin finished second, just ahead of the official Labour contender, Angeliki Stogia.
The unexpected outcome has sparked fresh debate of the party's controversial decision to prevent Andy Burnham from standing in the seat last month.
Speaking to the BBC, Labour's deputy leader, Lucy Powell, remarked, "Andy Burnham likely could have held the seat. I think certainly the Greens wouldn't have targeted the seat in the same way that they did."
Powell was the sole member of Labour's top decision-making body to support allowing Burnham to stand, with eight others, including leader Keir Starmer, voting against.
However, she stated she accepted "collective responsibility" for the ruling, pointing to worries over triggering a separate election in Greater Manchester.
Powell also stressed that her party needed to draw inspiration from the sources of Burnham's widespread popularity in the region. She said people "see in him someone who is on their side, someone who is implementing those Labour values and party pledges."
"We have to utilise that insight, make use of Andy Burnham, but also learn from it and consider how we could replicate that success across the country," she added.
Andy Burnham is reportedly considering another attempt at returning to parliament. A source close to him commented, "Given the current political climate, who knows what might happen. It would be foolish to say he would never."
To date, Burnham himself has yet to comment on the byelection result. Meanwhile, Keir Starmer has vowed to fight on despite labelling the poll result "disappointing."
Angela Rayner, a prominent voice on Labour's left, called the byelection result "a stark warning" for the party.
Meanwhile, the Home Secretary is expected to warn against the party moving to the left in response to the defeat. This comes as she introduces new laws on tougher immigration measures next week.
A source close to the Home Secretary was quoted as saying, "The party should not misinterpret the message from its electoral setback. The idea that we are losing Muslim voters over immigration is just plain wrong."
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